DepMap (Cancer Dependency Map)

Genome-scale CRISPR/RNAi essentiality across 1150 cancer cell lines + omics.

Composite

100.0

Experimental validation

Wet-lab confirmed

Stages

Target IDDisease Modeling

Modalities

cross-modality

Task types

essentialitybiomarker

Size

cell_lines: 1,150
genes: 18,000

License

CC-BY 4.0

First release

2017-07

Last updated

2025-06

Official site

Leaderboard

Dataset

Code / GitHub

HuggingFace

→ HF

Paper

Defining a Cancer Dependency Map · Tsherniak A, Vazquez F, Montgomery PG, et al. · 2017 · paper · doi:10.1016/j.cell.2017.06.010 · 2,600 citations

Flags

none

Experts

Aviad Tsherniak, William C. Hahn, Todd Golub

Groups

Broad DepMap

Hosted by

—

Related benchmarks

Open Targets Platform, LINCS L1000 / CMap

Rubric (7-criterion)

rigor

coverage

maintenance

adoption

quality

accessibility

industry_relevance

Notes

Quarterly release cadence.

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