Observed Antibody Space (OAS)

Repository of >1B antibody BCR sequences from public repertoires — core for antibody LM pretraining.

Composite

97.5

Experimental validation

Retrospective

Stages

Hit IDLead ID / ADMET

Modalities

biologic-mab

Task types

antibody-sequence

Size

sequences: 2,400,000,000
repertoires: 15,000

License

CC-BY 4.0

First release

2018

Last updated

2025-04

Official site

→ project page

Leaderboard

→ leaderboard

Dataset

→ dataset

Code / GitHub

→ repository

HuggingFace

→ HF

Paper

Observed Antibody Space: A diverse database of cleaned, annotated, and translated unpaired and paired antibody sequences · Olsen TH, Boyles F, Deane CM · 2022 · paper · doi:10.1002/pro.4205 · 310 citations

Flags

none

Experts

Charlotte Deane, Tobias Olsen

Groups

Oxford OPIG (Deane Lab)

Hosted by

—

Related benchmarks

SAbDab, CoV-AbDab, IgLM / AntiBERTa benchmarks

Rubric (7-criterion)

rigor

coverage

maintenance

adoption

quality

accessibility

industry_relevance

Notes

Underlies AbLang, IgLM, AntiBERTa — industry-adopted.

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