OffSides / TWOSIDES

Statistically corrected single- and pair-wise drug adverse events derived from FAERS.

Composite

83.0

Experimental validation

Retrospective

Stages

Post-market / RWE

Modalities

small-molecule

Task types

adverse-eventddi

Size

offsides_signals: 438,801
twosides_combos: 870,000

License

CC-BY 4.0

First release

2012

Last updated

2023-09

Official site

→ project page

Leaderboard

→ leaderboard

Dataset

→ dataset

Code / GitHub

→ repository

HuggingFace

→ HF

Paper

Data-driven prediction of drug effects and interactions · Tatonetti NP, Ye PP, Daneshjou R, Altman RB · 2012 · paper · doi:10.1126/scitranslmed.3003377 · 1,100 citations

Flags

none

Experts

Nick Tatonetti, Russ Altman

Groups

Tatonetti Lab (Cedars-Sinai)

Hosted by

FAERS / SIDER / OffSides / TWOSIDES, Therapeutics Data Commons (TDC)

Related benchmarks

SIDER, FAERS (raw)

Rubric (7-criterion)

rigor

coverage

maintenance

adoption

quality

accessibility

industry_relevance

Notes

Key benchmark for DDI + adverse event ML.

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