ProteinGym

217 DMS substitution assays + indel + clinical variants — de facto standard for VEPs.

Composite

97.5

Experimental validation

Wet-lab confirmed

Stages

Target IDLead ID / ADMETIND-enabling

Modalities

protein-general

Task types

variant-effect

Size

dms_assays: 217
mutations: 2,700,000
clinical_variants: 2,525

License

MIT

First release

2022

Last updated

2025-03

Official site

Leaderboard

Dataset

Code / GitHub

HuggingFace

→ HF

Paper

ProteinGym: Large-Scale Benchmarks for Protein Fitness Prediction and Design · Notin P, Kollasch A, Ritter D, et al. · 2023 · paper · doi:10.48550/arXiv.2305.06259 · 320 citations

Flags

none

Experts

Debora Marks, Pascal Notin, Yarin Gal

Groups

Marks Lab (Debora Marks), Oxford OATML

Hosted by

ProteinGym

Related benchmarks

FLIP

Rubric (7-criterion)

rigor

coverage

maintenance

adoption

quality

accessibility

industry_relevance

Notes

Field standard. Clinical track enables fair ESM/EVE/AlphaMissense comparison.

← Back to all benchmarks

Compare:

Open comparison →