DREAM Challenges
Long-running crowd-sourced biomedical prediction challenges, many pharma-sponsored.
Kind
competition
Composite
89.4
Benchmarks tracked
74
Direct-linked
29
As of
2026-05-12
Host organisation
Sage Bionetworks + IBM + academic partners
Primary contacts
Gustavo Stolovitzky, Justin Guinney, Pablo Meyer
Founded
2006
License model
Per-challenge (mostly CC-BY-NC)
Official site
GitHub
Count methodology
dreamchallenges.org/closed-challenges + /active as of 2026-05: 74 completed/active challenges; ~38 drug-discovery-relevant.
Rubric
rigor
5
coverage
4
maintenance
3
adoption
5
quality
5
accessibility
4
industry_relevance
5
Breakdown
drug_sensitivity
9
target_prediction
6
toxicity
5
disease_subtyping
12
other_biomed
42
Notes
Historical impact on field norms. Cadence has slowed 2022+.
Hosted benchmarks (29)
Direct-linked — each links to the benchmark’s leaderboard / detail page on the host portal.
DREAM Challenge (29)
NCI-DREAM Drug SensitivityDREAM ChallengeAstraZeneca-Sanger Drug Combination PredictionDREAM ChallengeDREAM5 Transcription Factor BindingDREAM ChallengeDREAM Pancancer Drug SensitivityDREAM ChallengeENCODE-DREAM TF BindingDREAM ChallengeDREAM Somatic Mutation CallingDREAM ChallengeDREAM Idea ChallengeDREAM ChallengeDREAM ProteogenomicsDREAM ChallengeDREAM Tumor DeconvolutionDREAM ChallengeDREAM Gene EssentialityDREAM ChallengeDREAM Single-Cell Data IntegrationDREAM ChallengeDREAM Pooled CRISPRDREAM ChallengeSC1 sc-RNAseq BenchmarkDREAM ChallengeDigital Mammography DREAMDREAM ChallengeAlzheimer’s DREAM ChallengeDREAM ChallengePreterm Birth DREAMDREAM ChallengeRA2 DREAM ChallengeDREAM ChallengeSleep Apnea Heart Rate DREAMDREAM ChallengeCancer Drug Response DREAMDREAM ChallengeSMC-Het DREAMDREAM ChallengeSMC-DNA DREAMDREAM ChallengeSMC-RNA DREAMDREAM ChallengeICGC-TCGA DREAMDREAM ChallengeProteogenomics NSCLC DREAMDREAM ChallengeBreast Cancer DREAMDREAM ChallengeMulti-Targeted QSAR DREAMDREAM ChallengeDREAM PANCAN SurvivalDREAM ChallengeEpitope DREAMDREAM ChallengeGene Expression DREAMDREAM Challenge