LINCS L1000 / CMap

1.3M transcriptional profiles across 978 landmark genes after genetic or chemical perturbations.

Composite

89.9

Experimental validation

Wet-lab confirmed

Stages

Virtual CellDisease ModelingTarget ID

Modalities

small-moleculecross-modality

Task types

signature-matchmechanism-of-action

Size

profiles: 1,319,138
compounds: 33,000
cell_lines: 82

License

CC-BY

First release

2017-11

Last updated

2024-03

Official site

→ project page

Leaderboard

→ leaderboard

Dataset

→ dataset

Code / GitHub

→ repository

HuggingFace

→ HF

Paper

A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles · Subramanian A, Narayan R, Corsello SM, et al. · 2017 · paper · doi:10.1016/j.cell.2017.10.049 · 3,700 citations

Flags

none

Experts

Aravind Subramanian, Todd Golub

Groups

Broad CMap

Hosted by

—

Related benchmarks

scPerturb, DepMap (Cancer Dependency Map)

Rubric (7-criterion)

rigor

coverage

maintenance

adoption

quality

accessibility

industry_relevance

Notes

Foundational pharma resource for MoA work. Batch effects require careful handling.

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