TDC DrugSyn (OncoPolyPharm + DrugComb_NCI60)

Drug combination synergy benchmark (NCI ALMANAC + OncoPolyPharmacology).

Composite

77.0

Experimental validation

Wet-lab confirmed

Stages

Developmental CandidateLead ID / ADMET

Modalities

small-molecule

Task types

drug-synergy

Size

combos: 23,000
cell_lines: 60

License

MIT

First release

2021-02

Last updated

2024-12

Official site

→ project page

Leaderboard

→ leaderboard

Dataset

→ dataset

Code / GitHub

→ repository

HuggingFace

→ HF

Paper

Therapeutics Data Commons · Huang K, Fu T, et al. · 2021 · paper · doi:10.48550/arXiv.2102.09548 · 620 citations

Flags

none

Experts

Kexin Huang, Marinka Zitnik

Groups

Therapeutics Data Commons, Zitnik Lab

Hosted by

Therapeutics Data Commons (TDC)

Related benchmarks

TDC ADMET Group, DepMap (Cancer Dependency Map)

Rubric (7-criterion)

rigor

coverage

maintenance

adoption

quality

accessibility

industry_relevance

Notes

Important for combination therapy design.

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